Role of hepatocytes and bile duct cells in preservation-reperfusion injury of liver grafts
Identifieur interne : 000995 ( Main/Exploration ); précédent : 000994; suivant : 000996Role of hepatocytes and bile duct cells in preservation-reperfusion injury of liver grafts
Auteurs : Marián Kukan [Canada] ; Pierre S. Haddad [Canada]Source :
- Liver Transplantation [ 1527-6465 ] ; 2001.
Abstract
In liver transplantation, it is currently hypothesized that nonparenchymal cell damage and/or activation is the major cause of preservation-related graft injury. Because parenchymal cells (hepatocytes) appear morphologically well preserved even after extended cold preservation, their injury after warm reperfusion is ascribed to the consequences of nonparenchymal cell damage and/or activation. However, accumulating evidence over the past decade indicated that the current hypothesis cannot fully explain preservation-related liver graft injury. We review data obtained in animal and human liver transplantation and isolated perfused animal livers, as well as isolated cell models to highlight growing evidence of the importance of hepatocyte disturbances in the pathogenesis of normal and fatty graft injury. Particular attention is given to preservation time-dependent decreases in high-energy adenine nucleotide levels in liver cells, a circumstance that (1) sensitizes hepatocytes to various stimuli and insults, (2) correlates well with graft function after liver transplantation, and (3) may also underlie the preservation time-dependent increase in endothelial cell damage. We also review damage to bile duct cells, which is increasingly being recognized as important in the long-lasting phase of reperfusion injury. The role of hydrophobic bile salts in that context is particularly assessed. Finally, a number of avenues aimed at preserving hepatocyte and bile duct cell integrity are discussed in the context of liver transplantation therapy as a complement to reducing nonparenchymal cell damage and/or activation. (Liver Transpl 2001;7:381-400.)
Url:
DOI: 10.1053/jlts.2001.23913
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Role of hepatocytes and bile duct cells in preservation-reperfusion injury of liver grafts</title><author><name sortKey="Kukan, Marian" sort="Kukan, Marian" uniqKey="Kukan M" first="Marián" last="Kukan">Marián Kukan</name></author><author><name sortKey="Haddad, Pierre S" sort="Haddad, Pierre S" uniqKey="Haddad P" first="Pierre S." last="Haddad">Pierre S. Haddad</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:DD1EF5DACD47A2FABB96472F7979C46787E9B3DC</idno><date when="2001" year="2001">2001</date><idno type="doi">10.1053/jlts.2001.23913</idno><idno type="url">https://api.istex.fr/document/DD1EF5DACD47A2FABB96472F7979C46787E9B3DC/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001095</idno><idno type="wicri:Area/Main/Curation">001052</idno><idno type="wicri:Area/Main/Exploration">000995</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Exploration">000995</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Role of hepatocytes and bile duct cells in preservation-reperfusion injury of liver grafts</title><author><name sortKey="Kukan, Marian" sort="Kukan, Marian" uniqKey="Kukan M" first="Marián" last="Kukan">Marián Kukan</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>From the *Laboratory of Perfused Organs, Slovak Centre for Organ Transplantation, Institute of Preventive and Clinical Medicine, Bratislava, Slovakia; and the †Groupe de Recherche en Transport Membranaire et Département de Pharmacologie, Université de Montréal, Montréal, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Haddad, Pierre S" sort="Haddad, Pierre S" uniqKey="Haddad P" first="Pierre S." last="Haddad">Pierre S. Haddad</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>From the *Laboratory of Perfused Organs, Slovak Centre for Organ Transplantation, Institute of Preventive and Clinical Medicine, Bratislava, Slovakia; and the †Groupe de Recherche en Transport Membranaire et Département de Pharmacologie, Université de Montréal, Montréal, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Liver Transplantation</title><title level="j" type="abbrev">YJLTS</title><idno type="ISSN">1527-6465</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2001">2001</date><biblScope unit="volume">7</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="381">381</biblScope><biblScope unit="page" to="400">400</biblScope></imprint><idno type="ISSN">1527-6465</idno></series><idno type="istex">DD1EF5DACD47A2FABB96472F7979C46787E9B3DC</idno><idno type="DOI">10.1053/jlts.2001.23913</idno><idno type="PII">S1527-6465(01)22733-6</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1527-6465</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In liver transplantation, it is currently hypothesized that nonparenchymal cell damage and/or activation is the major cause of preservation-related graft injury. Because parenchymal cells (hepatocytes) appear morphologically well preserved even after extended cold preservation, their injury after warm reperfusion is ascribed to the consequences of nonparenchymal cell damage and/or activation. However, accumulating evidence over the past decade indicated that the current hypothesis cannot fully explain preservation-related liver graft injury. We review data obtained in animal and human liver transplantation and isolated perfused animal livers, as well as isolated cell models to highlight growing evidence of the importance of hepatocyte disturbances in the pathogenesis of normal and fatty graft injury. Particular attention is given to preservation time-dependent decreases in high-energy adenine nucleotide levels in liver cells, a circumstance that (1) sensitizes hepatocytes to various stimuli and insults, (2) correlates well with graft function after liver transplantation, and (3) may also underlie the preservation time-dependent increase in endothelial cell damage. We also review damage to bile duct cells, which is increasingly being recognized as important in the long-lasting phase of reperfusion injury. The role of hydrophobic bile salts in that context is particularly assessed. Finally, a number of avenues aimed at preserving hepatocyte and bile duct cell integrity are discussed in the context of liver transplantation therapy as a complement to reducing nonparenchymal cell damage and/or activation. (Liver Transpl 2001;7:381-400.)</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Kukan, Marian" sort="Kukan, Marian" uniqKey="Kukan M" first="Marián" last="Kukan">Marián Kukan</name></noRegion><name sortKey="Haddad, Pierre S" sort="Haddad, Pierre S" uniqKey="Haddad P" first="Pierre S." last="Haddad">Pierre S. Haddad</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Musique/explor/SchutzV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000995 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000995 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Musique
|area= SchutzV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:DD1EF5DACD47A2FABB96472F7979C46787E9B3DC
|texte= Role of hepatocytes and bile duct cells in preservation-reperfusion injury of liver grafts
}}
| This area was generated with Dilib version V0.6.38. |  |